Bitter Melon Extract
22
2023
Sep
Food News Magazine 304: Plant Insulin - Introduction to Patented Amino Peptide Sequence mcIRBP-19
Plant Insulin – mcIRBP-19
Natural Key to Blood Sugar Regulation
Metabolic syndrome encompasses issues like abnormal blood lipids, blood sugar, and abdominal obesity (central obesity). Insulin resistance is the primary cause of metabolic syndrome. Prolonged poor blood sugar control can easily lead to diabetes and even other chronic diseases. According to statistics, the number of diabetes patients in Taiwan has exceeded 2.3 million, and the prevalence of metabolic syndrome in Taiwan is as high as 20%, with an increasing trend as the population ages. Driven by this substantial demand, bitter melon extract emerged, leading to their popularity in the market.
Bitter melon (Momordica charantia Linn.), a member of the Cucurbitaceae family, is a traditional Chinese herbal medicine. Many studies have confirmed that bitter melon contains various blood sugar-lowering components, primarily including terpenes, phytosterols, and peptides. There are many related products on the market extracted from bitter melon (see Table 1). The mechanisms of action range from improving insulin sensitivity, inhibiting glucose-degrading enzymes, to directly binding with insulin receptors. With various blood sugar regulation mechanisms, bitter melon has gained significant attention in the field of blood sugar control. However, research shows that if specific component structures are not extracted or if the product is only following market trends and not adequately utilized, over time, ineffective feedback from consumers may lead to market saturation, causing high-quality products to be overlooked.
In an environment saturated with products claiming to contain bitter melon peptides, many of these lack scientific validation of their functionality or physiological mechanisms. The market is chaotic, with products of varying quality. Due to the complex mechanism of blood sugar regulation, there is rarely a structure that can substitute for insulin in regulating blood sugar. It has been traditionally believed that small molecular peptides or large proteins with high absorption rates cannot bind to insulin receptors, thus their effectiveness is limited. However, some companies persist in conducting in-depth research on bitter melon, focusing on the essential nature of the plant. They have verified that the specific amino peptide sequence mcIRBP-19, consisting of 19 amino acids, is a rare natural substance that can directly bind to the diabetes-causing target - the insulin receptor. They have completed structural sequencing and quantitative analysis, providing scientific evidence that repeatedly confirms its unique physiological function. Additionally, they have conducted multiple in vivo functional studies, which are detailed as follows:
Regulating Blood Sugar and Assisting in the Treatment of Diabetes
Diabetes is an irreversible disease, and its alarming annual increase rate of 25,000 cases is not the only cause for concern. The complications it leads to, such as retinopathy, neuropathy, and cardiovascular diseases, are even more significant.
Through animal experiments analyzing fasting blood sugar and post-meal blood sugar regulation capabilities, it was found that the patented amino peptide sequence 19 (mcIRBP-19) can reduce fasting blood sugar by 50% and glycosylated hemoglobin by 38%. Additionally, it maintains a balanced insulin level in the body. Furthermore, it prevents a significant increase in post-meal blood sugar, rapidly regulating blood sugar within 2 hours. Its exceptional ability to stabilize blood sugar can significantly reduce the occurrence of complications caused by diabetes, such as retinopathy.
Human clinical studies have shown (4) that the patented amino peptide sequence 19 (mcIRBP-19) can assist in significantly reducing fasting blood sugar and glycosylated hemoglobin within 12 weeks for individuals who have shown insufficient improvement with conventional diabetes medication. It can also effectively improve the quality of life for patients (5). This clinical trial validates the potential effectiveness of mcIRBP-19.
Reducing Body Fat, Blood Lipids, and Anti-Inflammation
In addition to unstable blood sugar, metabolic syndrome also involves issues with abnormal blood lipids, central obesity, and chronic inflammation. Animal experiments (6) have shown that the patented amino peptide sequence 19 (mcIRBP-19) can regulate fatty acid metabolism and genes related to fatty liver. It effectively reduces body fat percentage by 25.5%, significantly decreasing white fat in the liver. This helps prevent the occurrence of fatty liver and avoids liver damage. Furthermore, chronic inflammation, much like an internal fire, can lead to various diseases, including cancer. The patented sequence 19 peptide can effectively reduce the expression of inflammatory factors in various organs, thus preventing the onset of chronic diseases.
The human body is like a machine. When metabolic syndrome occurs, it's like screws gradually loosening. Continued operation can easily lead to machine failure, resulting in conditions such as chronic diseases and cancer. At such times, we urgently need a helper who can tighten the screws.
The structure of mcIRBP-19, with the potential of a plant-derived insulin, is extracted using patented technology. The functional 19 amino acids are fully sequenced. Through a series of animal and clinical experiments, it has been confirmed to stabilize both pre-meal and post-meal blood sugar levels, reduce body fat and blood lipids, and achieve anti-inflammatory effects while providing adjunctive treatment for diabetes. This not only brings a ray of hope to diabetes patients, preventing the deterioration of their condition, but also takes into account their quality of life. It offers everyone a safe and effective natural preventive health option for daily life.
Natural Key to Blood Sugar Regulation
Author: Weixiu Zhuang
Introduction
Modern lifestyles characterized by irregular routines, high-fat and high-salt diets, and a preference for refined foods, coupled with busy schedules, high stress, overeating, and insufficient physical activity, have led to the emergence of the modern civilization ailment known as "metabolic syndrome."Metabolic syndrome encompasses issues like abnormal blood lipids, blood sugar, and abdominal obesity (central obesity). Insulin resistance is the primary cause of metabolic syndrome. Prolonged poor blood sugar control can easily lead to diabetes and even other chronic diseases. According to statistics, the number of diabetes patients in Taiwan has exceeded 2.3 million, and the prevalence of metabolic syndrome in Taiwan is as high as 20%, with an increasing trend as the population ages. Driven by this substantial demand, bitter melon extract emerged, leading to their popularity in the market.
Potential Plant Insulin
Bitter melon (Momordica charantia Linn.), a member of the Cucurbitaceae family, is a traditional Chinese herbal medicine. Many studies have confirmed that bitter melon contains various blood sugar-lowering components, primarily including terpenes, phytosterols, and peptides. There are many related products on the market extracted from bitter melon (see Table 1). The mechanisms of action range from improving insulin sensitivity, inhibiting glucose-degrading enzymes, to directly binding with insulin receptors. With various blood sugar regulation mechanisms, bitter melon has gained significant attention in the field of blood sugar control. However, research shows that if specific component structures are not extracted or if the product is only following market trends and not adequately utilized, over time, ineffective feedback from consumers may lead to market saturation, causing high-quality products to be overlooked.
Figure 1: Research on Commercial Bitter Melon Health Ingredients
| Ingredient | Charantin | Bitter Melon Peptide | ||
| Protein or Polypeptide | Patented amino peptide sequence 19 | Hydrolyzed peptide | ||
| Country of origin | India, China | India, America | Taiwan | Taiwan, China |
| Active ingredient | Saponins, cucurbitane Triterpenoids, charantin | Using bitter substances, charantin, or peptides with a molecular weight greater than 10,000Da | mcIRBP-19, molecular mass 2162Da | Small molecule peptide with no specific target for acid hydrolysis |
| Patent | None | Failed nor few patent | More than 20 multinational patents | None |
| Extraction method | Organic solvent extraction | Distilled water extraction | No organic solvent extraction | Acid hydrolysis |
| Sequence | None | Macromolecular with complex composition | Patented amino peptide sequence 19 | None, complex composition |
| Mechanism of action | Inhibit glucose and pancreatic lipase enzymes, thereby suppressing post-meal blood sugar levels | No research | Directly binding to insulin receptors and opening the glucose channels. | No research |
| International Journals & Research | Commercially available products, no specific study | None or informal | Five international journals, two clinical | none |
| Effective dosage for researchers | Extracted compound 4.6-4.92g, calculated | 2419 mg, calculated based | 300-600 mg | No official research |
Patented Amino Peptide Sequence mcIRBP-19
In an environment saturated with products claiming to contain bitter melon peptides, many of these lack scientific validation of their functionality or physiological mechanisms. The market is chaotic, with products of varying quality. Due to the complex mechanism of blood sugar regulation, there is rarely a structure that can substitute for insulin in regulating blood sugar. It has been traditionally believed that small molecular peptides or large proteins with high absorption rates cannot bind to insulin receptors, thus their effectiveness is limited. However, some companies persist in conducting in-depth research on bitter melon, focusing on the essential nature of the plant. They have verified that the specific amino peptide sequence mcIRBP-19, consisting of 19 amino acids, is a rare natural substance that can directly bind to the diabetes-causing target - the insulin receptor. They have completed structural sequencing and quantitative analysis, providing scientific evidence that repeatedly confirms its unique physiological function. Additionally, they have conducted multiple in vivo functional studies, which are detailed as follows:
Regulating Blood Sugar and Assisting in the Treatment of Diabetes
Diabetes is an irreversible disease, and its alarming annual increase rate of 25,000 cases is not the only cause for concern. The complications it leads to, such as retinopathy, neuropathy, and cardiovascular diseases, are even more significant.
Through animal experiments analyzing fasting blood sugar and post-meal blood sugar regulation capabilities, it was found that the patented amino peptide sequence 19 (mcIRBP-19) can reduce fasting blood sugar by 50% and glycosylated hemoglobin by 38%. Additionally, it maintains a balanced insulin level in the body. Furthermore, it prevents a significant increase in post-meal blood sugar, rapidly regulating blood sugar within 2 hours. Its exceptional ability to stabilize blood sugar can significantly reduce the occurrence of complications caused by diabetes, such as retinopathy.
Human clinical studies have shown (4) that the patented amino peptide sequence 19 (mcIRBP-19) can assist in significantly reducing fasting blood sugar and glycosylated hemoglobin within 12 weeks for individuals who have shown insufficient improvement with conventional diabetes medication. It can also effectively improve the quality of life for patients (5). This clinical trial validates the potential effectiveness of mcIRBP-19.
Reducing Body Fat, Blood Lipids, and Anti-Inflammation
In addition to unstable blood sugar, metabolic syndrome also involves issues with abnormal blood lipids, central obesity, and chronic inflammation. Animal experiments (6) have shown that the patented amino peptide sequence 19 (mcIRBP-19) can regulate fatty acid metabolism and genes related to fatty liver. It effectively reduces body fat percentage by 25.5%, significantly decreasing white fat in the liver. This helps prevent the occurrence of fatty liver and avoids liver damage. Furthermore, chronic inflammation, much like an internal fire, can lead to various diseases, including cancer. The patented sequence 19 peptide can effectively reduce the expression of inflammatory factors in various organs, thus preventing the onset of chronic diseases.
Conclusion
The human body is like a machine. When metabolic syndrome occurs, it's like screws gradually loosening. Continued operation can easily lead to machine failure, resulting in conditions such as chronic diseases and cancer. At such times, we urgently need a helper who can tighten the screws.
The structure of mcIRBP-19, with the potential of a plant-derived insulin, is extracted using patented technology. The functional 19 amino acids are fully sequenced. Through a series of animal and clinical experiments, it has been confirmed to stabilize both pre-meal and post-meal blood sugar levels, reduce body fat and blood lipids, and achieve anti-inflammatory effects while providing adjunctive treatment for diabetes. This not only brings a ray of hope to diabetes patients, preventing the deterioration of their condition, but also takes into account their quality of life. It offers everyone a safe and effective natural preventive health option for daily life.
Reference
Wang HY, et al. Food Chem Toxicol. (2014) 69:347-356.
Dallas LC, et al. J Med Food. (2011) 14:1496-1504.
Lo HY, et al. J Agric Food Chem. (2013) 61:2461-2468.
Hsu PK, et al. Nutrients (2020) 12:1252.
Pan F, et al. Risk Manag Healthc Policy. (2020) 13:2219-2226.
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